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2 The canonical Wnt pathway, also known as the Wnt/-catenin pathway, involves the nuclear translocation of -catenin and activation of target genes via TCF/LEF transcription factors

Metal complexation with copper and palmitoylation (creating Pal-GHK) both increase permeability, and cell-penetrating peptides and microneedle pretreatment show promise as enhancement strategies

In preclinical studies, compounds such as VX-765 and pralnacasan have demonstrated efficacy in inhibiting caspase-1 activation and protecting against inflammatory diseases

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves -cell mass in non-obese diabetic mice

Berberine inhibits ferroptosis and stabilizes atherosclerotic plaque through NRF2/SLC7A11/GPX4 pathway